How BioWave® Works

BioWave® Non-Surgical High Frequency
Peripheral Nerve Stimulation

How does BioWave®’s proprietary signal
technology work?

BioWave® devices alternate the delivery of two summed high frequency sinusoidal alternating current signals (4062 hz + 3940 hz), back and forth to two independent electrodes. The high frequency signals are able to bypass the impedance of skin and travel into deep tissue beneath and surrounding each electrode.(1) 

As the high frequency signals contact polarized structures inside the body, such as the plus charge sitting at the membrane of the C-fiber, A-delta fiber or muscle tissue, the two high frequencies are multiplied together resulting in a new spectrum of frequencies that form an active electrical field in a 3.5 inch diameter hemisphere (think of half of a grapefruit) beneath each 2” diameter electrode sitting at the surface of the skin. This active electrical field is comprised of 3 high frequency components (8002 hz, 4062 Hz, 3940 Hz), one low frequency component (122 hz) and harmonics on the low frequency, which contribute to hyperpolarize pain nerve fibers, preventing the sodium-potassium ion exchange across the membrane of C-fibers, interrupting action potential propagation along pain nerves, and preventing the transmission of the pain signal to the brain. The active electrical field also induces hypoesthesia on A-delta fibers about 5 minutes into the treatment and the loss of proprioception and light numbness lasts typically for 30 minutes post treatment in the regions beneath and surrounding each electrode. Patients receive immediate pain relief as they increase the intensity of the active electrical field as well as a long carry over effect following the 30-minute treatment. Residual pain relief lasts post-treatment for 8 hours on average(3) and can last up to 72 hours depending on the type of BioWave® device and electrode used on the patient.(2,3)

(1) Rabbit Study, Frequency Spectrum Analysis, US Patent, FDA 510k Application
(2)Cornell Phase 3 BioWave vs TENS blinded randomized controlled crossover study on Chronic Low Back Pain.
(3) High Frequency Peripheral Nerve Stimulation Peer Reviewed Published Paper

Easy to Use

Because the active electrical field forms in the hemisphere directly beneath and surrounding each electrode, electrode placement is intuitive. The electrodes must be placed directly over locations of pain or over the origin of pain and the most proximal location of pain relative to the origin.
Additionally our first dosage study at Weill Cornell Medical College determined that if the body could produce an electrical field that encompasses pain nerves at a specific low frequency, it caused the greatest reduction in VAS pain scores from before to after the treatment. This allowed us to a design a very simple to use device – there’s no programming. The only control is the intensity and patients control their own comfort level by pressing a plus or minus button on the face of the device.

BioWave goes deeper

BioWave’s patented high frequency neurostimulation is delivered through skin directly to pain nerves, inhibiting action potential propagation along the nerve, blocking the transmission of pain signals to the brain.

Innovative deep relief

Antiquated shallow reach


of patients reported an improvement in quality of life after using BioWave for two weeks (1)

8 hours

of pain relief on average following a 30-minute treatment

3.47 points

average reduction in pain score (0-10 scale) after using BioWave for two weeks(2)


of patients reduced or eliminated their pain medication consumption after using BioWave for two weeks(1)

(1)Open Label Pilot Study Investigating Non invasive High-Frequency Peripheral Nerve Fiber Stimulation In Chronic Pain Patients. Outcomes from 463 study participants, published in the peer reviewed journal Pain Practice from the World Institute of Pain.
(2)Reduced Pain and Improved Function Following Short-Term Use of Noninvasive BioWave High-Frequency Peripheral Nerve Stimulation for Pain Management. Open-label survey of 1,511 chronic pain patients published in the peer reviewed journal Pain and Therapy.


Does BioWaveGO Come With A Warranty?

BioWave is proud to offer a 1 year warranty on all products..  If your device should fail for any reason, we will replace it free of charge, no hassle and no waiting for a repair. For warranty questions or to place a warranty request, please call BioWave Customer service at 877-246-9283 X 1. Thank you for trusting BioWave.

Is BioWave Different Than TENS?

Yes, BioWave is superior to TENS because BioWave blocks the pain signal at pain nerves in deep tissue. TENS just acts as a distraction at the surface of the skin.

What Is The Difference Between BioWavePRO, BioWaveHOME And BioWaveGO

BioWavePRO, BioWaveHOME, and BioWaveGO all utilize BioWave’s patented smarter pain blocking technology that works by delivering therapeutic electrical signals through skin into deep tissue right to the surface of pain fibers blocking the transmission of pain signals to the brain. BioWavePRO is a larger portable more ruggedized unit with a much larger battery system designed to be used all day long in a commercial setting like a hospital, physician’s office, physical therapy clinic or athletic training room.  BioWaveHOME is a prescription strength smaller handheld unit with a smaller battery system that is designed to be used by an individual patient at home. BioWaveGO is a small wearable over the counter strength unit that can be purchased without a prescription. For more information, please contact us or reach out to us at or at 1-877-BIOWAVE (1-877-246-9283). Thank you for your interest.

I Am An Athletic Trainer / Physical Therapist, How Do I Get A BioWavePRO?

You can order a BioWavePRO directly from BioWave.  BioWave units are covered by workers compensation as well as secondary insurance. Please contact us at or at 1-877-BIOWAVE (1-877-246-9283) and we can answer any questions you may have as well as take your order. Thank you for your interest.